Mayo Clinic Cancer Center team in Arizona completes whole human genome sequence on patient with blood cancer

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The concept of personalized medical treatment based on a patient’s DNA is one small step closer to becoming a reality.

A Mayo Clinic Cancer Center team in Arizona recently completed its first whole human genome sequencing on a patient suffering from multiple myeloma, a cancer of the bone marrow.

In a matter of weeks, the Mayo Clinic team, led by hematologist Dr. Keith Stewart and Dr. Jan Egan, a post doctoral fellow, in conjunction with Dr. John Carpten and a team of researchers at the Translational Genomics Research Institute (TGen) in downtown Phoenix, completed multiple copies of a whole human genome sequence, capturing an entire snapshot of the patient’s bone marrow cancer cells through various stages of the disease.

“We were interested in establishing the reasons why cancer patients become resistant to chemotherapy drugs or alternatively, why they are sensitive to the drugs in the first place,” said Dr. Stewart, of the groundbreaking research project which sequenced approximately 60 billion different DNA bases in less than a month after the patient’s samples had been prepared. 

This genetic research project was a first for the Mayo Clinic Cancer Center and a key milestone on the way to individualized genome based cancer care.

While the practice of genomic sequencing has been around for nearly a decade, Dr. Stewart said this Mayo Clinic-led project was particularly unique in that genetic samples were gathered at four different time intervals over the course of about four years, ranging from the onset of the malignant cancer diagnosis to the patient’s third relapse of the disease.

“We think by studying the whole genome rather than one gene at a time, we’ll be able to pinpoint genetic mutations which make this cancer resistant to chemotherapy,” said Dr. Stewart, explaining this whole genome sequence has the potential to reveal clues which may help pave the way for the development of new cancer fighting drugs or circumvent resistance to current chemotherapy drugs.

Want to learn more? In the video below Dr. Stewart speaks about this groundbreaking project. 

This post was submitted by communications consultant

Julie Janovsky-Mason at Mayo Clinic in Arizona.

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4 Responses to “Mayo Clinic Cancer Center team in Arizona completes whole human genome sequence on patient with blood cancer”

  1. Diana Cutler Says:

    My husband has MM. He has been on Velcade twice a week for 6 months. At this time his doctor is recommending a bone marrow transplant. We talked to a transplant doctor and she could not tell us if this was the way to go. I have done a lot of research on this and have not found it to be be a real answer.

    I do know if you use certain medicine it precludes you from doing something else. Our doctor is saying there is no research being done on this disease. Was grateful to read your article. Maybe there is hope.

  2. Julia Aldrich Says:

    If you could notify me of follow-ups I would like it. Thank you Julia

  3. Julia Aldrich Says:

    What a wonderful thing to have a promise that one day they might cure multiple myeloma. My mother died from this in 1997. It is indeed a painful death. They thought her father might of had it but are not sure. I am so gald that they are doing research on this. Thank you so much.

  4. pat brown Says:

    O M G!!!!! That is huge. Congrats to all. I know it took a village. I’m in awe that I have lived long enough to see this break through. I have no degrees, but I have always had an interest in this area and have followed all the steps with great interest. My Hubby works for Mayo, so as a family we are all proud of you. Major Kisses and Hugs for all of you.

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